Screening the United States Blood Supply for West Nile Virus: A Question of Blood, Dollars, and Sense
نویسندگان
چکیده
February 2006 | Volume 3 | Issue 2 | e99 Now that the media frenzy over West Nile virus (WNV) has subsided, and pictures of dead birds and insect repellant cans no longer permeate the nightly news, what shall we do about screening the United States blood supply for the virus? Shortly after the spread of WNV in North America and the revelation that blood transfusions may transmit the virus [1], US offi cials established regulations requiring blood banks to screen all their donated blood for WNV using nucleic acid amplifi cation tests. Although these requirements have been in place since June 2003, there has been debate over if and how to continue the screening [2,3]. The threat of disease certainly still exists, but with limited resources and other potential hazards to blood supply safety, there has been a real need for good, objective economic studies to determine what type and what degree of screening should be performed.
منابع مشابه
The cost-effectiveness of screening the U.S. blood supply for West Nile virus.
BACKGROUND The spread of West Nile virus across North America and evidence of transmission by transfusion prompted the U.S. Food and Drug Administration to encourage the development of methods to screen the blood supply. OBJECTIVE To assess the cost-effectiveness of nucleic acid amplification testing for West Nile virus in the U.S. blood supply. DESIGN Markov cohort simulation. DATA SOURC...
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National blood donor screening for West Nile virus (WNV) RNA using minipool nucleic acid amplification testing (MP-NAT) was implemented in the United States in July 2003. We compiled national NAT yield data and performed WNV immunoglobulin M (IgM) testing in 1 WNV-epidemic region (North Dakota). State-specific MP-NAT yield, antibody seroprevalence, and the average time RNA is detectable by MP-N...
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Over the past decade, West Nile virus (WNV) has spread across the United States. We aggregated blood donor data from 2010-2012 and then calculated the incidence of WNV RNA-positive donations and compared the incidence with neuroinvasive disease (NID) case data from the ArboNET surveillance system. Of 10,107,853 donations, 640 were confirmed positive. The seasonal WNV incidence rate per 100,000 ...
متن کاملTransfusion-associated transmission of West Nile virus, United States 2003 through 2005.
BACKGROUND National blood donation screening for West Nile virus (WNV) started in June 2003, after the documentation of WNV transfusion-associated transmission (TAT) in 2002. STUDY DESIGN AND METHODS Blood donations were screened with investigational nucleic acid amplification assays in minipool formats. Blood collection agencies (BCAs) reported screening results to state and local public hea...
متن کاملFatal West Nile Virus Infection After Probable Transfusion-Associated Transmission — Colorado, 2012
West Nile virus (WNV) is transmitted to humans primarily by infected mosquitoes. However, WNV also can be transmitted through infected blood products or solid organs (1). Since 2003, the U.S. blood supply has been routinely screened for WNV RNA. The Food and Drug Administration (FDA) recommends that blood collection agencies perform WNV nucleic acid testing (NAT) year-round on all blood donatio...
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ورودعنوان ژورنال:
- PLoS Medicine
دوره 3 شماره
صفحات -
تاریخ انتشار 2006